In vitro activities of six fluoroquinolones against 250 clinical isolates of Mycobacterium tuberculosis susceptible or resistant to first-line antituberculosis drugs.

نویسندگان

  • M J Ruiz-Serrano
  • L Alcalá
  • L Martínez
  • M Díaz
  • M Marín
  • M J González-Abad
  • E Bouza
چکیده

Two hundred fifty isolates of Mycobacterium tuberculosis were evaluated for susceptibility to ciprofloxacin, ofloxacin, levofloxacin, grepafloxacin, trovafloxacin, and gemifloxacin (SB-265805). Levofloxacin, ciprofloxacin, and grepafloxacin showed the greatest activity (MIC for 90% of strains tested [MIC(90)] 1 microg/ml), although ofloxacin also showed good activity, with an MIC(90) of 2 microg/ml. Trovafloxacin and gemifloxacin showed lower in vitro activity, with MIC(90)s of 64 and 8 microg/ml, respectively.

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منابع مشابه

Comparative in vitro activity of fluoroquinolones against Mycobacterium tuberculosis.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 44 9  شماره 

صفحات  -

تاریخ انتشار 2000